Model fitted: LME or GEE model
log(hormones) ~ Study + GA at sampling + Study:GA at sampling LME only: Random intercepts for Study ID and Plate GEE only: Independence correlation structure
14.2.1 Global tests
Type III ANOVA on main and interaction effects, and LM model summaries.
PRL (ng/ml)
Chisq
Df
Pr(>Chisq)
(Intercept)
21.782244
1
<0.0001
***
Study
1.759986
1
0.2
ns
GA_samp
37.833421
1
<0.0001
***
Study:GA_samp
1.825160
1
0.2
ns
hPL (μg/ml)
Chisq
Df
Pr(>Chisq)
(Intercept)
107.37637
1
<0.0001
***
Study
63.37312
1
<0.0001
***
GA_samp
115.88145
1
<0.0001
***
Study:GA_samp
71.34390
1
<0.0001
***
GH2 (ng/ml)
Chisq
Df
Pr(>Chisq)
(Intercept)
9.974225
1
0.002
**
Study
26.572090
1
<0.0001
***
GA_samp
57.571753
1
<0.0001
***
Study:GA_samp
26.560416
1
<0.0001
***
Insulin (uU/ml)
model term
df1
df2
F.ratio
Chisq
p.value
1
Study
1
Inf
3.706
3.706
0.05
ns
3
GA_samp
1
Inf
0.183
0.183
0.7
ns
2
Study:GA_samp
1
Inf
2.665
2.665
0.1
ns
HOMA-IR
model term
df1
df2
F.ratio
Chisq
p.value
1
Study
1
Inf
4.810
4.810
0.03
*
3
GA_samp
1
Inf
0.432
0.432
0.5
ns
2
Study:GA_samp
1
Inf
2.900
2.900
0.09
ns
Glucose (mmol/L)
model term
df1
df2
F.ratio
Chisq
p.value
1
Study
1
Inf
0.138
0.138
0.7
ns
3
GA_samp
1
Inf
0.001
0.001
1.0
ns
2
Study:GA_samp
1
Inf
0.190
0.190
0.7
ns
14.2.2 Model summary
Ratio of Geometric means (95% CI)
PRL (ng/ml)
Var
Effect
P
(Intercept)
2.14 (1.24, 3.03)
<0.0001
StudySTOP
0.63 (-0.30, 1.56)
0.18
GA_samp
0.18 (0.12, 0.24)
<0.0001
StudySTOP:GA_samp
-0.04 (-0.10, 0.02)
0.18
hPL (μg/ml)
Var
Effect
P
(Intercept)
2.53 (2.04, 3.01)
<0.0001
StudySTOP
-2.02 (-2.52, -1.52)
<0.0001
GA_samp
0.17 (0.14, 0.20)
<0.0001
StudySTOP:GA_samp
0.14 (0.11, 0.18)
<0.0001
GH2 (ng/ml)
Var
Effect
P
(Intercept)
-1.04 (-1.70, -0.38)
0.002
StudySTOP
-1.77 (-2.45, -1.08)
<0.0001
GA_samp
0.16 (0.12, 0.20)
<0.0001
StudySTOP:GA_samp
0.12 (0.07, 0.16)
<0.0001
Insulin (uU/ml)
Var
Effect
P
(Intercept)
3.45 (2.16, 4.73)
<0.0001
StudySTOP
-1.31 (-2.64, 0.02)
0.05
GA_samp
-0.05 (-0.13, 0.04)
0.27
StudySTOP:GA_samp
0.07 (-0.01, 0.16)
0.10
HOMA-IR
Var
Effect
P
(Intercept)
2.16 (0.83, 3.50)
0.001
StudySTOP
-1.55 (-2.94, -0.16)
0.03
GA_samp
-0.06 (-0.14, 0.03)
0.21
StudySTOP:GA_samp
0.08 (-0.01, 0.17)
0.09
Glucose (mmol/L)
Var
Effect
P
(Intercept)
1.66 (1.30, 2.02)
<0.0001
StudySTOP
-0.07 (-0.43, 0.29)
0.71
GA_samp
0.00 (-0.02, 0.03)
0.84
StudySTOP:GA_samp
-0.01 (-0.03, 0.02)
0.66
14.2.3 Diagnostics
Model diagnositcs.
Diagnositcs for PRL (ng/ml)
Diagnositcs for hPL (μg/ml)
Diagnositcs for GH2 (ng/ml)
Diagnositcs for Insulin (uU/ml)
Diagnositcs for HOMA-IR
Diagnositcs for Glucose (mmol/L)
14.2.4 Estimated means
Estimated marginal means (or adjusted means) adjusted for GA at sampling.
PRL (ng/ml)
Study
GA_samp
response
SE
df
lower.CL
upper.CL
SCOPE
10
51.11441
8.906805
1114.07386
36.31267
71.94962
STOP
10
62.65847
4.432004
69.44323
54.41322
72.15314
SCOPE
16
150.41614
10.759690
72.33237
130.42768
173.46791
STOP
16
142.93995
12.259227
148.33938
120.65629
169.33912
hPL (μg/ml)
Study
GA_samp
response
SE
df
lower.CL
upper.CL
SCOPE
10
67.92125
6.0306146
1668.81645
57.06556
80.84205
STOP
10
37.36817
0.9095297
93.09186
35.60500
39.21865
SCOPE
16
187.35085
4.6396951
97.63587
178.36571
196.78863
STOP
16
242.41586
8.6131317
388.30674
226.05960
259.95557
GH2 (ng/ml)
Study
GA_samp
response
SE
df
lower.CL
upper.CL
SCOPE
10
1.7651770
0.2079050
779.4183
1.4008017
2.224333
STOP
10
0.9757305
0.0225094
193.2049
0.9323297
1.021152
SCOPE
16
4.6213763
0.1093036
180.9841
4.4106582
4.842161
STOP
16
5.1643805
0.2209490
1235.9833
4.7485975
5.616569
Insulin (uU/ml)
Study
GA_samp
response
SE
df
asymp.LCL
asymp.UCL
SCOPE
10
19.77659
4.6279509
Inf
12.50145
31.28545
STOP
10
11.15166
0.3842101
Inf
10.42348
11.93070
SCOPE
16
14.96218
0.6124863
Inf
13.80862
16.21210
STOP
16
13.12747
0.9877112
Inf
11.32756
15.21337
HOMA-IR
Study
GA_samp
response
SE
df
asymp.LCL
asymp.UCL
SCOPE
10
5.004074
1.2160703
Inf
3.107908
8.057111
STOP
10
2.360224
0.0858766
Inf
2.197770
2.534686
SCOPE
16
3.587401
0.1563751
Inf
3.293639
3.907364
STOP
16
2.735166
0.2179779
Inf
2.339631
3.197568
Glucose (mmol/L)
Study
GA_samp
response
SE
df
asymp.LCL
asymp.UCL
SCOPE
10
5.395297
0.3344260
Inf
4.778085
6.092238
STOP
10
4.773670
0.0366162
Inf
4.702440
4.845979
SCOPE
16
5.475695
0.0719187
Inf
5.336536
5.618483
STOP
16
4.691147
0.0561450
Inf
4.582385
4.802490
14.2.5 Comparisons
Hormone
Contrast
GA_samp
Ratio of Geometric means (95% CI)
P-value
PRL (ng/ml)
STOP / SCOPE
10
1.23 (0.89, 1.69)
0.2
PRL (ng/ml)
STOP / SCOPE
16
0.95 (0.84, 1.07)
0.4
hPL (μg/ml)
STOP / SCOPE
10
0.55 (0.46, 0.65)
<0.0001
hPL (μg/ml)
STOP / SCOPE
16
1.29 (1.21, 1.38)
<0.0001
GH2 (ng/ml)
STOP / SCOPE
10
0.55 (0.44, 0.70)
<0.0001
GH2 (ng/ml)
STOP / SCOPE
16
1.12 (1.02, 1.22)
0.01
Insulin (uU/ml)
STOP / SCOPE
10
0.56 (0.35, 0.90)
0.02
Insulin (uU/ml)
STOP / SCOPE
16
0.88 (0.74, 1.04)
0.1
HOMA-IR
STOP / SCOPE
10
0.47 (0.29, 0.76)
0.002
HOMA-IR
STOP / SCOPE
16
0.76 (0.64, 0.91)
0.003
Glucose (mmol/L)
STOP / SCOPE
10
0.88 (0.78, 1.00)
0.05
Glucose (mmol/L)
STOP / SCOPE
16
0.86 (0.83, 0.89)
<0.0001
14.2.6 Barplots by Study
Barplots in this section may be misleading due to involvement of Study by GA interaction.